GL Semenza - Studies on Renal Disorders, 2011 - Springer Abstract The hypoxia-inducible factors (HIFs) are transcriptional activators that mediate homeostatic responses to hypoxia. At the cellular level, HIF-1 mediates adaptive metabolic responses to hypoxia that serve to maintain energy and redox homeostasis by reducing mitochondrial ... Related articles - All 2 versions
Y Xue, NL Li, JY Yang, Y Chen… - American Journal of …, 2011 - Am Physiological Soc We have previously demonstrated the roles of RhoA, Rac1, and Cdc42 in hypoxia-driven angiogenesis. However, the role of oncogenes in hypoxia signaling is poorly understood. Given the importance of Rho proteins in the hypoxic response, we hypothesized that Rho family ... Related articles - All 3 versions
DJ Klemm, SM Majka, JT Crossno Jr… - Journal of …, 2011 - journals.lww.com Hypoxia-induced pulmonary arterial hypertension (PAH) is a deadly disease characterized by progressive remodeling and persistent vasoconstriction of the pulmonary arterial (PA) system. Remodeling of the PA involves smooth muscle cell (SMC) proliferation, ... All 3 versions
LA Palmer, WJ May, K deRonde… - American Journal of …, 2011 - Am Thoracic Soc ... Convention Center Ventilatory Responses During And Following Exposure To Hypoxia In Conscious Mice Deficient Or Null In S-Nitrosoglutathione Reductase ... Exposure to hypoxia elicits an increase in Minute Ventilation (MV) that diminishes with continued exposure (roll-off). ... All 3 versions
WR Wilson… - Nature Reviews Cancer, 2011 - nature.com Hypoxia is a feature of most tumours, albeit with variable incidence and severity within a given patient population. It is a negative prognostic and predictive factor owing to its multiple contributions to chemoresistance, radioresistance, angiogenesis, vasculogenesis, invasiveness, ... Cited by 3 - Related articles - All 3 versions
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