WS Kim, AF Hill, ML Fitzgerald… - … of Alzheimer's Disease, 2011 - IOS Press Cerebral amyloid-β (Aβ) deposition is a critical feature of Alzheimer's disease. Aβ is derived from the amyloid-β protein precursor (AβPP) via two sequential cleavages that are mediated by β-secretase and the γ-secretase complex. Such amyloidogenic AβPP processing ...
[PDF] from amazonaws.comRJ Suetani, B Sorrenson, JDA Tyndall… - Atherosclerosis, 2011 - Elsevier Sequence alignments and modeling indicated residue R1068 to be located in an α-helix downstream of the Walker B motif in the first nucleotide binding domain (NBD-1), in a position to form ionic interactions with D1092 and E1093. Cholesterol efflux studies showed the efflux from TD ...
C Palacio, I Alexandraki… - Annals of Clinical & …, 2011 - Assoc Clin Scientists Tangier disease (familial alpha lipoprotein deficiency) is a rare genetic disorder of lipid metabolism characterized principally by a severe deficiency of high density lipoprotein (HDL), accompanied by low plasma levels of low density lipoprotein (LDL) cholesterol, normal or elevated ...
GU Denk, C Aslanidis, G Schmitz… - Experimental and …, 2011 - thieme-connect.com ... Key words. low HDL - hypoalphalipoproteinaemia - Tangierdisease. ... Defects in the genes encoding for apolipoprotein AI (apolipoprotein AI deficiency), LCAT (LCAT deficiency, fish eye disease), and ABCA1 (Tangierdisease) are well-understood causes for HDL deficiency. ... Related articles - All 4 versions
HB Brewer - Atlas of Atherosclerosis and Metabolic Syndrome, 2011 - Springer ... Structural defects in the apo AI gene complex, familial hypoalphalipoproteinemia, and Tangier disease, as well as patients with elevated triglycerides, dense low-density lipoprotein and low HDL, and the metabolic syndrome, have an increased risk of early heart disease. ... Cited by 1 - Related articles - All 2 versions
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