A Vachani, E Moon… - Current Treatment Options in Oncology, 2011 - Springer ... Adeno-associated virus The adeno-associated virus (AAV) [8, 9] is a defectiveparvovirus with a single strand DNA genome and a naked protein coat. AAV has not been associated with any known human disease state, suggesting a significant safety margin for this vector. ... All 3 versions
P Plevka, S Hafenstein, L Li, A D'Abrgamo Jr… - Journal of …, 2011 - Am Soc Microbiol ... While some of these modifications rendered capsids temperature sensitive or unconditionally defective for assembly and/or subsequent cell entry, one mutant (L172W ... pore, indicating that the channel along one of the 5-fold axes is the packaging portal for the parvovirus genome ... Related articles - All 4 versions
[HTML] from plos.orgM Fragkos… - PloS one, 2011 - dx.plos.org ... In this work we have probed cell death in mitosis by using a virus, adeno-associated virus (AAV), which is a replication-defectiveparvovirus containing a 4.7 kb single-stranded DNA genome [26]. AAV can induce a DNA damage ... Cached
M Zhang, H Yuan, Z Huang… - Zhong nan da xue xue bao. Yi …, 2011 - ncbi.nlm.nih.gov ... Center of Clinical Pharmacology, Third Xiangya Hospital; School of Pharmaceutical Sciences, Central South University, Changsha 410013, China. Objective Methods Results Conclusion Adeno-associated virus is a kind of DNA defectiveparvovirus which is non-pathogenic. ...
PE Monahan, RJ Samulski… - US Patent 7,923,436, 2011 - Google Patents ... 12, 2011 (54) METHODS AND COMPOUNDS FOR CONTROLLED RELEASE OF RECOMBINANT PARVOVIRUS VECTORS (75) Inventors: Paul E. Monahan, Chapel Hill, NC (US); Richard Jude Samulski, Chapel Hill, NC (US); Joseph E. Rabinowitz, Carrboro, NC (US) (73 ... Related articles - All 3 versions
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