[PDF] from qimr.edu.auJ Yang, MN Weedon, S Purcell… - … Journal of Human …, 2011 - genepi.qimr.edu.au Population structure, including population stratification and cryptic relatedness, can cause spurious associations in genome-wide association studies (GWAS). Usually, the scaled median or mean test statistic for association calculated from multiple single- nucleotide-polymorphisms ... Cited by 1 - View as HTML - All 6 versions
ES Gershon, N Alliey-Rodriguez… - American Journal of …, 2011 - Am Psychiatric Assoc ... 1–3). (Effect strength is measured as the odds ratio of an allele or genotype frequency in patients relative to comparison subjects.) An additional but still modest proportion of disease variance appears to be accounted for in the same GWAS studies by polygenicinheritance (4 ... Cited by 3 - Related articles - All 4 versions
G Davies, A Tenesa, A Payton, J Yang… - Molecular …, 2011 - nature.com ... We recently showed that when investigating a trait under polygenicinheritance, increasing the sample size would indeed be expected to increase the inflation factor. ... Genomic inflation factors under polygenicinheritance. Eur J Hum Genet 2011; 19: 807–812. ... Cited by 2
A Fassio, L Patry, S Congia, F Onofri… - Human Molecular …, 2011 - Oxford Univ Press ... 70–90%) of monozygotic twins compared with dizygotic twins (0–10%) (3,4). Overall, genetic epidemiology studies suggest an interaction between several epistatic genes (polygenic inheritance), although the mechanism of inheritance of ASDs remains largely unknown (5). The ... Cited by 2 - Related articles - All 4 versions
M Gilling, A Lind-Thomsen, Y Mang, M Bak… - European Journal of …, 2011 - Elsevier ... However, since a bi- or polygenicinheritance model is 66 relevant for some forms of MR [7] we specifically chose to investigate all chromosomal 67 breakpoints in a male twin couple with MR who had inherited a translocation from their 68 phenotypically normal father and an ... All 2 versions
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