GL Semenza - Studies on Renal Disorders, 2011 - Springer Abstract The hypoxia-inducible factors (HIFs) are transcriptional activators that mediate homeostatic responses to hypoxia. At the cellular level, HIF-1 mediates adaptive metabolic responses to hypoxia that serve to maintain energy and redox homeostasis by reducing mitochondrial ... Related articles - All 2 versions
K Sritharan, T Lane, K Duong, IJ Franklin… - …, 2011 - phleb.rsmjournals.com Method: Patients referred to a vascular surgery clinic at Charing Cross Hospital, for management of their CVD, were invited to complete a validated questionnaire relating to disease-specific quality of life (Aberdeen Varicose Veins Questionnaire [AVVQ]) and depressive symptoms ...
Y Xue, NL Li, JY Yang, Y Chen… - American Journal of …, 2011 - Am Physiological Soc We have previously demonstrated the roles of RhoA, Rac1, and Cdc42 in hypoxia-driven angiogenesis. However, the role of oncogenes in hypoxia signaling is poorly understood. Given the importance of Rho proteins in the hypoxic response, we hypothesized that Rho family ... Related articles - All 3 versions
LA Palmer, WJ May, K deRonde… - American Journal of …, 2011 - Am Thoracic Soc ... Convention Center Ventilatory Responses During And Following Exposure To Hypoxia In Conscious Mice Deficient Or Null In S-Nitrosoglutathione Reductase ... Exposure to hypoxia elicits an increase in Minute Ventilation (MV) that diminishes with continued exposure (roll-off). ... All 3 versions
WR Wilson… - Nature Reviews Cancer, 2011 - nature.com Hypoxia is a feature of most tumours, albeit with variable incidence and severity within a given patient population. It is a negative prognostic and predictive factor owing to its multiple contributions to chemoresistance, radioresistance, angiogenesis, vasculogenesis, invasiveness, ... Cited by 3 - Related articles - All 3 versions
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