[PDF] from mit.eduY Erlich, S Edvardson, E Hodges, S Zenvirt… - Genome …, 2011 - genome.cshlp.org Whole exome sequencing has become a pivotal methodology for rapid and cost-effective detection of pathogenic variations in Mendelian disorders. A major challenge of this approach is determining the causative mutation from a substantial number of bystander variations that do not play ... Cited by 5 - Related articles - All 8 versions
LA Pinto, B Galvão, RC Junior… - REVISTA …, 2011 - revistacienciasmedicaspe.com.br Background: The spontaneous proliferation of PBMCs in individuals infected with the Human T-Lymphocyte Virus (HTLV) type-1 is mainly induced by the viral protein Tax. Aim: To evaluate the spontaneous proliferation of T-cell subsets from asymptomatic HTLV-1 infected ... Cached - All 2 versions
P Kirk, A Witkover, A Courtney, A Lewin… - …, 2011 - retrovirology.com The pathogenesis of HAM remains uncertain: the disease is thought to be caused by the immune response to HTLV-1, possibly by bystander damage to neurons in the spinal cord. The strongest correlate of HAM in HTLV-1-infected individuals is the proviral load of HTLV-1, ie the ... Cached - All 4 versions
K Ueda, M Ishihara, A Osawa, N Senkoji, N Araya… - Retrovirology, 2011 - Springer Human T-lymphotropic virus type-1 (HTLV-1) can cause the development of HTLV-1 associated myelopa- thy/ tropical spastic paraparesis (HAM/TSP) and adult T-cell leukemia (ATL). These nervous system inflamma- tion and cancer occur only in a very small proportion of ... All 5 versions
C Alberti, L Cartier, MA Valenzuela… - Journal of Medical …, 2011 - Wiley Online Library There is no effective therapy for human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Glucocorticoids are effective to reduce the motor disability in these patients, but its role as anti-spastic drugs is unknown. Here it is ... Related articles - All 2 versions
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