AG Schepers, R Vries, M Van Den Born… - The EMBO …, 2011 - nature.com Somatic cells have been proposed to be limited in the number of cell divisions they can undergo. This is thought to be a mechanism by which stem cells retain their integrity preventing disease. However, we have recently discovered intestinal crypt stem cells that persist for ... Cited by 5 - Related articles - All 4 versions
[HTML] from pnas.orgRK Montgomery, DL Carlone… - Proceedings of the …, 2011 - National Acad Sciences The intestinal epithelium is maintained by a population of rapidly cycling (Lgr5 + ) intestinal stem cells (ISCs). It has been postulated, however, that slowly cycling ISCs must also be present in the intestine to protect the genome from accumulating deleterious mutations and to allow ... Cited by 10 - Related articles - All 4 versions
Q Zhang, NK Kim… - … of the National Academy of Sciences …, 2011 - ncbi.nlm.nih.gov Telomerase is a unique reverse transcriptase that catalyzes the addition of telomere DNA repeats onto the 3' ends of linear chromosomes and plays a critical role in maintaining genome stability. Unlike other reverse transcriptases, telomerase is unique in that it is a ...
HC Ferreira, B Luke, H Schober, V Kalck… - Nature Cell …, 2011 - nature.com Budding yeast telomeres are reversibly bound at the nuclear envelope through two partially redundant pathways that involve the Sir2/3/4 silencing complex and the Yku70/80 heterodimer 1, 2 . To better understand how this is regulated, we studied the role of SUMOylation in telomere ... All 3 versions
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