FG Smith, JE Fewell… - Clinical and Experimental …, 2011 - Wiley Online Library ... 2 Following exposure to a blood-borne exogenouspyrogen such as lipopolysaccharide (LPS), cells of the immune system synthesize and secrete endogenous pyrogens, including interleukin (IL)-1β, IL-6 and tumour necrosis factor-α, 3 which results in the production of cyclo ...
PA Ward - Shock, 2011 - journals.lww.com ... Although exogenouspyrogens such as LPS are well known to induce fever, it is unclear if they are responsible for induction of the prefebrile variations in temperature patterns described in this report and featuring patients with gram-negative bacteremia. ...
MS Oakley, N Gerald, TF McCutchan, L Aravind… - Trends in …, 2011 - Elsevier ... IL-6, as well as complement factor 5a (C5a) and prostaglandin E 2 (PGE 2 ) [7]. Phagocytic monocytes in peripheral tissues have been shown to be important sources of these endogenous pyrogens in response to the exogenouspyrogens derived from pathogenic organisms. ...
DJ Niven, C Leger, HT Stelfox… - Journal of Intensive …, 2011 - jic.sagepub.com ... In this model, the exogenouspyrogen (LPS) activates mononuclear phagocytic cells to produce endo- genous pyrogenic cytokines such as those listed in Table 1.17 These molecules are transported via the blood to circumventri- cular organs where they cross the blood-brain ... Related articles - All 3 versions
BP Srivastava… - US Patent 20,110,171,330, 2011 - freepatentsonline.com ... A pyrogen may be endogenous or exogenous to the body. The bacterial substance lipopolysaccharide (LPS) is an example of an exogenouspyrogen and certain cytokines produced by phagocytic cells are exemplary endogenous pyrogens. ... Cached
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