RL Paquette, J Nicoll, M Chalukya, D Elashoff… - Cancer Genetics, 2011 - Elsevier Clinical variables associated with ecotropic viral integration site 1 (EVI1) translocations were evaluated in 42 consecutive chronic myeloid leukemia (CML) patients in myeloid blast crisis (MBC). Translocations were confirmed with fluorescence in situ hybridization, and ...
RK Sachs, K Johnsson, P Hahnfeldt, J Luo, A Chen… - Cancer research, 2011 - AACR Chronic myeloid leukemia (CML) is characterized by a specific chromosome translocation, and its pathobiology is considered comparatively well understood. Thus, quantitative analysis of CML and its progression to blast crisis may help elucidate general mechanisms of ... Cited by 1 - Related articles - All 4 versions
K Sakai, Y Ishikawa, Y Mori, M Kobayashi… - International journal of …, 2011 - Springer Abstract BCR-ABL kinase domain mutations were sequentially analyzed in a patient with chronic myeloid leukemia (CML) who exhibited repeated B-lymphoid blast crisis (CML-BC) during treatment with imatinib and dasatinib. We first identified five mutant BCR-ABL clones: Y253H, ... Cited by 1 - Related articles - All 3 versions
C Matte-Martone, S Venkatesan… - The Journal of …, 2011 - Am Assoc Immnol Graft-versus-leukemia (GVL) against chronic-phase chronic myelogenous leukemia (CP-CML) is potent, but it is less efficacious against acute leukemias and blast-crisis chronic myelogenous leukemia (BC-CML). The mechanisms underlying GVL resistance are ...
LF Peterson, E Mitrikeska, D Giannola, Y Lui… - Leukemia, 2011 - nature.com Philadelphia chromosome positive chronic myeloid leukemia has a progressive course starting in a benign phase and terminating in a blastic phase. In this study, we show that human homolog double minute 2 (HDM2) inhibition, with MI-219—a novel compound, and consequently ... All 4 versions
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