MF Gregor… - Annual review of immunology, 2011 - ncbi.nlm.nih.gov The modern rise in obesity and its strong association with insulin resistance and type 2 diabetes have elicited interest in the underlying mechanisms of these pathologies. The discovery that obesity itself results in an inflammatory state in metabolic tissues ushered in a research ... Cited by 12 - Related articles
W Huang, S Ghisletti, K Saijo, M Gandhi, M Aouadi… - Nature, 2011 - nature.com Toll-like receptors (TLRs) function as initiators of inflammation through their ability to sense pathogen-associated molecular patterns and products of tissue damage 1, 2 . Transcriptional activation of many TLR-responsive genes requires an initial de-repression step in which ... Cited by 4 - Related articles - All 5 versions
LA Faine, M Rudnicki, FA César… - Current medicinal …, 2011 - ncbi.nlm.nih.gov Thiazolidinediones (TZDs) are a class of drugs used for treatment of type 2 diabetes. However, the therapy with currently available TDZs (eg rosiglitazone) is associated with important side effects, such as edema and weight gain, suggesting that the investigation of ...
G Hotamisligil - Annual Review of Immunology, 2011 - annualreviews.org The modern rise in obesity and its strong association with insulin resistance and type 2 diabetes have elicited interest in the underlying mechanisms of these pathologies. The discovery that obesity itself results in an inflammatory state in metabolic tissues ushered in a research ... Related articles
BZ Qian, J Li, H Zhang, T Kitamura, J Zhang… - Nature, 2011 - nature.com Macrophages, which are abundant in the tumour microenvironment, enhance malignancy 1 . At metastatic sites, a distinct population of metastasis-associated macrophages promotes the extravasation, seeding and persistent growth of tumour cells 2 . Here we define the origin ... Cited by 6 - Related articles - All 3 versions
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