R Agarwal, LA MacMillan-Crow, TM Rafferty… - … of Pharmacology and …, 2011 - ASPET In overdose the analgesic/antipyretic acetaminophen (APAP) is hepatotoxic. Toxicity is mediated by initial hepatic metabolism to N-acetyl-p-benzoquinone imine (NAPQI). After low doses NAPQI is efficiently detoxified by GSH. However, in overdose GSH is depleted, NAPQI covalently ... Cited by 1 - Related articles - All 3 versions
YW Chung, HK Kim, IY Kim, MB Yim… - Journal of Biological …, 2011 - ASBMB 12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown to induce transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA in human lung carcinoma cells, A549, mediated by a protein kinase C (PKC)-dependent activation of cAMP- ...
HE Lob, A Vinh, L Li, Y Blinder, S Offermanns… - …, 2011 - ncbi.nlm.nih.gov Previous studies indicate that superoxide is important in the modulation of blood pressure but have not specifically identified the cell types or organs involved. We created mice with loxP sites flanking the extracellular superoxide dismutase (SOD3) gene. These mice were crossed ... All 2 versions
Z Van Rheen, C Fattman, S Domarski… - American journal of …, 2011 - ncbi.nlm.nih.gov ... 2011 Apr;44(4):500-8. Epub 2010 Jun 10. Lung extracellular superoxidedismutase overexpression lessens bleomycin-induced pulmonary hypertension and vascular remodeling. Van Rheen Z, Fattman C, Domarski S, Majka S, Klemm D, Stenmark KR, Nozik-Grayck E. ...
H Korekane, A Korekane, Y Yamaguchi… - Glycoconjugate …, 2011 - Springer Abstract Extracellular superoxide dismutase (EC-SOD), the major SOD isoenzyme in biological fluids, is known to be N-glycosylated and heterogeneous as was detected in most glycoproteins. However, only one N-glycan structure has been reported in recombinant ... Related articles - All 5 versions
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