H Hosomi, T Fukami, A Iwamura, M Nakajima… - Drug Metabolism and …, 2011 - ASPET ... would be associated with the hepatotoxicity, in human liver microsomes. These ... Flutamide is reported be oxidized into reactive metabolites that covalently bind to microsomal proteins ... investigate the drug-induced cytotoxicity mediated by CYPs, but this system generally ... Cited by 1 - Related articles - All 2 versions
A Iwamura, T Fukami, H Hosomi, M Nakajima… - Drug Metabolism and …, 2011 - ASPET ... could form protein or glutathione adducts by incubation with human liver microsomes and/or ... rat liver after oral administration, although it did not bind to microsomal protein in ... constructed a highly sensitive cell-based assay system to evaluate CYP2C9-mediated cytotoxicity and ... Cited by 1 - Related articles - All 4 versions
J Topinka, P Rossner Jr, A Milcova, J Schmuczerova… - Toxicology letters, 2011 - Elsevier ... Both effects are enhanced by metabolic activation by microsomal cytochrome P-450 enzymes. ... Acellular assay to assess genotoxicity of complex mixtures of organic pollutants bound ... Effect of cancer chemopreventive agents on microsome-mediated DNA adduction of the breast ... Cited by 1 - Related articles - All 3 versions
CA Erratico, SC Moffatt… - Toxicological Sciences, 2011 - Soc Toxicology ... conducted using heat-denatured microsomes. Hepatic microsome samples were boiled for 5 min ... incubation mixture containing assay buffer, microsomes, and NADPH prior to use. Preliminary experiments were conducted to determine the most active microsomal preparation ... Related articles - All 2 versions
HJ Choi, SH Park, J Kim, KH Do… - Biochemical and Biophysical …, 2011 - Elsevier ... presence or absence of 10 M indomethacin for 24 h. Culture supernatant was analyzed for the PGE2 secretion using an enzyme-linked immunosorbent assay. ... [20] Y. Moon, WC Glasgow, TE Eling, Curcumin suppresses interleukin 1beta-mediatedmicrosomal prostaglandin E ...
沪公网安备号：31010402006960 （网站）31010405000484 （蝌蝌APP）
安全保密
