[HTML] from plos.orgLF Ciufo, PA Murray, A Thompson, DJ Rigden… - PloS one, 2011 - dx.plos.org Most species of invertebrate animals cannot synthesise sterols de novo and many that feed on plants dealkylate phytosterols (mostly C 29 and C 28 ) yielding cholesterol (C 27 ). The final step of this dealkylation pathway involves desmosterol reductase (DHCR24)-catalysed ... Related articles - Cached - All 3 versions
[PDF] from peerproject.euV Urlacher, L Liu… - 2011 - repository.peerproject.eu Abstract Cytochrome P450 monooxygenase CYP- 116B3 from Rhodococcus ruber catalyzes the deal- kylation of 7-ethoxycoumarin and the hydroxylation of substituted and unsubstituted aromatics. How- ever, since activities were quite low, a combination of site-specific ... Related articles
ME Dowty, G Hu, F Hua, FB Shilliday… - International Journal of …, 2011 - ijt.sagepub.com Abstract In the process of drug design, it is important to consider potential structural alerts that may lead to toxicosis. This work illustrates how using trifluoroethane as a part of a novel chemical entity led to cytochrome P450 – mediated N-dealkylation and the formation of ...
ML Tomazic, SR Najle, AD Nusblat… - Eukaryotic …, 2011 - Am Soc Microbiol The gene TTHERM_00438800 (DES24) from the ciliate Tetrahymena thermophila encodes a protein with three conserved histidine clusters, typical of the fatty acid hydroxylase superfamily. Despite its high similarity to sterol desaturase-like enzymes, the phylogenetic ... Related articles - All 3 versions
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