D Egan, J Kim, RJ Shaw… - Autophagy, 2011 - ncbi.nlm.nih.gov The serine/threonine kinase ULK1 is a mammalian homolog of Atg1, part of the Atg1 kinase complex, which is the most upstream component of the core autophagy machinery conserved from yeast to mammals. In budding yeast, activity of the Atg1 kinase complex is inhibited ... Cited by 1 - All 5 versions
E Moussay, T Kaoma, J Baginska, A Muller… - Autophagy, 2011 - ncbi.nlm.nih.gov While the autophagic process is mainly regulated at the post-translational level, a growing body of evidence suggests that autophagy might also be regulated at the transcriptional level. The identification of transcription factors involved in the regulation of autophagy genes has ... All 5 versions
M Graef… - Autophagy, 2011 - ncbi.nlm.nih.gov Understanding the functional relationship between mitochondria and autophagy is critical for understanding the molecular mechanisms underlying ageing and neurodegeneration. Autophagy functions in both cellular homeostasis and in quality control in the selective removal of ... All 5 versions
MK McCoy… - Autophagy, 2011 - ncbi.nlm.nih.gov The dysregulation of mitochondrial function has been implicated in the pathogenesis of Parkinson disease. Mutations in the parkin, PINK1, and DJ-1 genes all result in recessive parkinsonism. Although the protein products of these genes have not been fully ... All 5 versions
H Li, P Wang, J Yu… - Autophagy, 2011 - ncbi.nlm.nih.gov Autophagy is often found in apoptosis-defective cancer cells and contributes to chemotherapy resistance. However, it is far from clear how the coordination of apoptosis and autophagy determines sensitivity of cancer cells to chemotherapy. Our recent study showed that Beclin 1, a key ... All 5 versions
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