KA Salminen, A Meyer, L Jerabkova, LE Korhonen… - Phytomedicine, 2011 - Elsevier The human cytochrome P450 (CYP) enzymes play a major role in the metabolism of endobiotics and numerous xenobiotics including drugs. Therefore it is the standard procedure to test new drug candidates for interactions with CYP enzymes during the preclinical development ... All 3 versions
A Nakagawa, H Minami, JS Kim… - Nature …, 2011 - nature.com The secondary metabolites of higher plants include diverse chemicals, such as alkaloids, isoprenoids and phenolic compounds (phenylpropanoids and flavonoids). Although these compounds are widely used in human health and nutrition, at present they are mainly obtained by ... All 3 versions
AL Harvey, LC Young, AM Viljoen… - Journal of …, 2011 - Elsevier The South African plant Sceletium tortuosum has been known for centuries for a variety of traditional uses, and, more recently, as a possible source of anti-anxiety or anti-depressant effects. A standardised extract Zembrin® was used to test for pharmacological activities that might be relevant to ...
P De Frenne, A Kolb, BJ Graae, G Decocq… - Plant …, 2011 - Wiley Online Library ... to increased chemical seed defence. The most widespread secondary compounds involved in chemical plant defence containing N and occur- ring in the Ranunculaceae are alkaloids (Larcher 2003). There- fore, we used a ... Related articles - All 7 versions
A Ivanova, J Serly, V Christov, B Stamboliyska… - Fitoterapia, 2011 - Elsevier ... Vinca alkaloids are substrates of ABC-type drug exporters but also inhibitors [9]. Based on these observations we focused our recent research on the MDR inhibitory effects of various plant alkaloids. ...Alkaloids comprise one of the largest groups of plant secondary metabolites. ... Related articles - All 4 versions
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