A Lu, M Miao, TR Schoeb, A Agarwal… - The American Journal of …, 2011 - Elsevier Transforming growth factor-β (TGF-β) is key in the pathogenesis of diabetic nephropathy. Thrombospondin 1 (TSP1) expression is increased in diabetes, and TSP1 regulates latent TGF-β activation in vitro and in diabetic animal models. Herein, we investigate the effect of blockade of TSP1- ... Related articles - All 4 versions
B Rooney, H O'Donovan, A Gaffney, M Browne… - FEBS letters, 2011 - Elsevier We describe the activation of Wnt signalling in mesangial cells by CCN2. CCN2 stimulates phosphorylation of LRP6 and GSK-3β resulting in accumulation and nuclear localisation of β-catenin, TCF/LEF activity and expression of Wnt targets. This is coincident with decreased phosphorylation ... Cited by 3 - Related articles - All 3 versions
J Manchanayake, S Chitturi, C Nolan… - Journal of …, 2011 - Wiley Online Library Background and Aims: Despite strong associations between non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D), it is unclear which patients need oral glucose tolerance testing (OGTT). Relationships between hyperglycemia, postprandial hyperinsulinemia ... Cited by 1 - Related articles - All 4 versions
[PDF] from journalofdiabetology.orgUS Sharma… - Journal of Diabetology, 2011 - journalofdiabetology.org Alloxan (2, 4, 5, 6-tetraoxypyrimidine; 2, 4, 5, 6-pyrimidinetetrone) is a toxic glucose analogue, which selectively destroys insulin-producing pancreatic β-cells and causes a non-insulin-dependent diabetes mellitus (NIDDM), when administered to animal species. ... Related articles - View as HTML - All 2 versions
O Chan, S Paranjape, D Czyzyk, A Horblitt… - Diabetes, 2011 - Am Diabetes Assoc OBJECTIVE Impaired glucose counterregulation during hypoglycemia is well documented in patients with type 1 diabetes; however, the molecular mechanisms underlying this defect remain uncertain. We reported that the inhibitory neurotransmitter γ-aminobutyric acid (GABA), in ... All 3 versions
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