LS Steelman, RA Franklin, SL Abrams, W Chappell… - Leukemia, 2011 - nature.com The Ras/Raf/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway is often implicated in sensitivity and resistance to leukemia therapy. Dysregulated signaling through the Ras/Raf/MEK/ERK pathway is often the result of genetic alterations ... Cited by 1 - Related articles - All 3 versions
PA Greif, SH Eck, NP Konstandin, A Benet-Pagès… - Leukemia, 2011 - nature.com Genetic lesions are crucial for cancer initiation. Recently, whole genome sequencing, using next generation technology, was used as a systematic approach to identify mutations in genomes of various types of tumors including melanoma, lung and breast cancer, as well as acute ... Cited by 1 - Related articles - All 4 versions
R Ibbotson, A Athanasiadou, LA Sutton, Z Davis… - Leukemia, 2011 - nature.com Trisomy 12 is a recurrent chromosomal aberration occurring in 10–20% of CLL that has been associated with an intermediate risk. 1, 2 A small percentage, between 1.6 and 5%, of patients with trisomy 12 also have trisomy 19 and may constitute a distinct subgroup. 3, 4, 5 This ...
X Zhang, M Reis, R Khoriaty, Y Li, P Ouillette… - Leukemia, 2011 - nature.com The pathogenesis of chronic lymphocytic leukemia (CLL) remains incompletely understood. 1 Although acquired chromosomal aberrations have been demonstrated to influence CLL biology and clinical behavior, it remains unclear what single gene defects other than p53 or ATM ... All 3 versions
AM Martelli, C Evangelisti, W Chappell, SL Abrams… - Leukemia, 2011 - nature.com It has become apparent that regulation of protein translation is an important determinant in controlling cell growth and leukemic transformation. The phosphoinositide 3-kinase (PI3K)/phosphatase and tensin homologue deleted on chromosome ten (PTEN)/Akt/mammalian target of ... Cited by 1 - Related articles - All 3 versions
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