A Innocenzi, L Latella, G Messina, M Simonatto… - EMBO reports, 2011 - nature.com Despite having distinct expression patterns and phenotypes in mutant mice, the myogenic regulatory factors Myf5 and MyoD have been considered to be functionally equivalent. Here, we report that these factors have a different response to DNA damage, due to the presence in MyoD ... All 3 versions
L Notley, KH Crewe… - ASCEPT Annual …, 2011 - espace.library.uq.edu.au ... The biotransformation of tamoxifen by human vytochrome P450 enzymes leads to the production of potentially genotoxic metabolites. ... The biotransformation of tamoxifen by human vytochrome P450 enzymes leads to the production of potentially genotoxic metabolites. ... Cached - All 3 versions
S Mehta, E Huillard, S Kesari, CL Maire… - Cancer Cell, 2011 - Elsevier High-grade gliomas are notoriously insensitive to radiation and genotoxic drugs. Paradoxically, the p53 gene is structurally intact in the majority of these tumors. Resistance to genotoxic modalities in p53-positive gliomas is generally attributed to attenuation of p53 ... All 2 versions
MH Lee, AM Mabb, GB Gill, ET Yeh… - Molecular cell, 2011 - ncbi.nlm.nih.gov Activation of NF-κB, pivotal for immunity and oncogenesis, is tightly controlled by multiple feedback mechanisms. In response to DNA damage, SUMOylation of NEMO (NF-κB essential modulator) is critical for NF-κB activation; however, the SUMO proteases and feedback ...
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