B Rooney, H O'Donovan, A Gaffney, M Browne… - FEBS letters, 2011 - Elsevier We describe the activation of Wnt signalling in mesangial cells by CCN2. CCN2 stimulates phosphorylation of LRP6 and GSK-3β resulting in accumulation and nuclear localisation of β-catenin, TCF/LEF activity and expression of Wnt targets. This is coincident with decreased phosphorylation ... Cited by 3 - Related articles - All 3 versions
S Khan, S Lakhe-Reddy, JH McCarty… - The American Journal of …, 2011 - Elsevier Integrins are heterodimeric receptors that regulate cell adhesion, migration, and apoptosis. Integrin αvβ8 is most abundantly expressed in kidney and brain, and its major ligand is latent transforming growth factor-β (TGF-β). Kidney αvβ8 localizes to mesangial cells, which appose ... Cited by 1 - Related articles - All 4 versions
F Krötz - American Journal of Physiology-Renal Physiology, 2011 - Am Physiological Soc Toll-like receptor subtype 3 (TLR3) is a unique member of the TLR family of innate immune receptors. In contrast to most TLRs, which are can be activated by either bacterial, fungal, or unknown stimuli, TLR3 is the only TLR subtype that can be activated by double-stranded ... Related articles - All 3 versions
MS Simonson… - Journal of Biological Chemistry, 2011 - ASBMB Endothelin-1 (ET-1), a potent vasoconstrictor, has been implicated in the pathogenesis of collagen accumulation, extracellular matrix remodeling, and renal and cardiac fibrosis in diabetes. However, the mechanism by which ET-1 promotes collagen accumulation remains ... Related articles - All 3 versions
I Loeffler, U Hopfer, D Koczan… - Journal of the American …, 2011 - Am Soc Nephrol Mesangial cells in diabetic mice and human kidneys with diabetic nephropathy exhibit increased type VIII collagen, a nonfibrillar protein that exists as a heterodimer composed of α1(VIII) and α2(VIII), encoded by Col8a1 and Col8a2, respectively. Because TGF-β1 promotes the ... All 4 versions
沪公网安备号：31010402006960 （网站）31010405000484 （蝌蝌APP）
安全保密
