D Demirbas, O Ceyhan, AR Wyman… - … as Drug Targets, 2011 - Springer Abstract Fission yeast strains have been engineered so that their growth behavior reflects the activity of heterologous cyclic nucleotide phosphodiesterases (PDEs). These strains can be used in High-Throughput Screens (HTSs) for PDE inhibitors that possess “drug-like” ... Related articles - All 2 versions
GW Hoyle, W Chang, J Chen… - American Journal of …, 2011 - Am Thoracic Soc ... The Type 4 PhosphodiesteraseInhibitor Rolipram Ameliorates Chlorine-Induced Acute Lung Injury In Mice , W ... Rolipram is an inhibitor of type 4 phosphodiesterase and increases cAMP levels by inhibiting cAMP hydrolysis. The ... All 3 versions
[HTML] from plos.orgM Kiebala… - PloS one, 2011 - dx.plos.org Human Immunodeficiency Virus-1 (HIV-1)-associated neurocognitive disorders (HAND) occur, in part, due to the inflammatory response to viral proteins, such as the HIV-1 transactivator of transcription (Tat), in the central nervous system (CNS). Given the need for novel ... Related articles - Cached - All 3 versions
[PDF] from biomedcentral.comR Lewis, J Connor, J Teerlink, J Murphy, L Cooper… - Trials, 2011 - biomedcentral.com Background: Claudication secondary to peripheral artery disease (PAD) is associated with substantial functional impairment. Phosphodiesterase (PDE) inhibitors have been shown to increase walking performance in these patients. K- 134 is a selective PDE 3 inhibitor being developed as a ... Related articles - View as HTML - All 14 versions
RA Samangaya, M Wareing… - Hypertension in …, 2011 - informahealthcare.com Objective. To determine if the phosphodiesterase type 5 inhibitor, sildenafil citrate improves endothelial-dependent relaxation of small arteries from women with preeclampsia. Methods. Myometrial and omental biopsies were taken from women participating in a randomized ... Related articles - All 3 versions
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