[HTML] from pnas.orgLD Jennings-Antipov, L Song… - Proceedings of the …, 2011 - National Acad Sciences The protective antigen (PA) moiety of anthrax toxin forms oligomeric pores that translocate the enzymatic moieties of the toxin—lethal factor (LF) and edema factor (EF)—across the endosomal membrane of mammalian cells. Here we describe site-directed spin-labeling studies that ... Cited by 2 - Related articles - All 5 versions
CR Smith, GK Smith, Z Yang, D Xu… - … Chemistry Accounts: Theory, …, 2011 - Springer Abstract We report a hybrid quantum mechanical and molecular mechanical study of the catalysis of anthrax lethal factor. The calculations suggest that the zinc peptidase uses the same general base-general acid mechanism as in thermolysin and carboxypeptidase A, ... Related articles - All 3 versions
AE Boyer, CP Quinn, CA Beesley… - Journal of Infectious …, 2011 - jid.oxfordjournals.org Cutaneous anthrax outbreaks occurred in Bangladesh from August to October 2009. As part of the epidemiological response and to confirm anthrax diagnoses, serum samples were collected from suspected case patients with observed cutaneous lesions. Anthrax lethal factor (LF), ...
SR Crowe, L Garman, RJM Engler, AD Farris… - Vaccine, 2011 - Elsevier The efficacy biomarker of the currently licensed anthrax vaccine (AVA) is based on quantity and neutralizing capacity of anti-protective antigen (anti-PA) antibodies. However, animal studies have demonstrated that antibodies to lethal factor (LF) can provide protection ... Related articles - All 3 versions
S Kim, GS Jiao, M Moayeri, D Crown… - Bioorganic & medicinal …, 2011 - Elsevier New anthrax lethal factor inhibitors (LFIs) were designed based upon previously identified potent inhibitors 1a and 2. Combining the new core structures with modifications to the C2- side chain yielded analogs with improved efficacy in the rat lethal toxin model. All 3 versions
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