MB Overdijk, S Verploegen… - The Journal of …, 2011 - Am Assoc Immnol Ab-dependent cellular cytotoxicity (ADCC) is recognized as a prominent cytotoxic mechanism for therapeutic mAbs in vitro. However, the contribution of ADCC to in vivo efficacy, particularly for treatment of solid tumors, is still poorly understood. For zalutumumab, a therapeutic ...
B Cheng, SK Maffi, AA Martinez, YPV Acosta… - Molecular and Cellular …, 2011 - Elsevier The proteasome is an enzyme complex responsible for targeted intracellular proteolysis. Alterations in proteasome-mediated protein clearance have been implicated in the pathogenesis of aging, Alzheimer's disease (AD) and Parkinson's disease (PD). In such diseases, ... All 2 versions
K Rajasekaran, H Chu, P Kumar, Y Xiao… - Journal of Biological …, 2011 - ASBMB Carma1, a caspase recruitment domain-containing membrane-associated guanylate kinase, initiates a unique signaling cascade via Bcl10 and Malt1 in NK cells. Carma1 deficiency results in reduced phosphorylation of JNK1/2 and activation of NF-κB that lead to impaired NK ...
E Moga, E Cantó, S Vidal, C Juarez, J Sierra… - Experimental …, 2011 - Elsevier Chemoimmunotherapy with anti-CD20 monoclonal antibody rituximab is increasingly used for the treatment of patients with chronic lymphocytic leukemia (CLL). Antibody-dependent cytotoxicity (ADCC) is one of the most important mechanisms of action of rituximab against B-cell ...
S Sheikpranbabu, R Haribalaganesh… - Diabetes & …, 2011 - ncbi.nlm.nih.gov AIM: This study investigated the effects of pigment epithelium-derived factor (PEDF) on advanced glycation end-product (AGE)-induced cytotoxicity in porcine retinal pericytes and the signalling mechanism involved. METHODS: Retinal pericytes were isolated from porcine eyes and ...
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