J Brouwers, K Vermeire, C Grammen, D Schols… - Antiviral Research, 2011 - Elsevier In the search for a successful HIV microbicide, many poorly water-soluble antiviral agents are currently being investigated. Unfortunately, solubility and precipitation issues may limit intravaginal concentrations and thus availability of these agents upon application of an aqueous gel ... All 4 versions
M Donia, D Maksimovic-Ivanic… - Cell cycle ( …, 2011 - ncbi.nlm.nih.gov The NO-derivative of the HIV protease inhibitor saquinavir (Saq-NO) is a nontoxic variant of the parental drug with enhanced anticancer activity on several cell lines. However, it is still unclear whether the p53 status of the target cell might influence the sensitivity to Saq-NO. In this ... All 6 versions
H Knechten, C Stephan, FA Mosthaf… - European journal of …, 2011 - ncbi.nlm.nih.gov Objective: We have previously reported data from the German cohort of the multinational observational prospective RAINBOW survey which assessed the tolerability and efficacy of ritonavir-boosted saquinavir (SQV/r)-containing regimens over 48 weeks in routine clinical practice. This ...
X Zhang, S Fettner, E Zwanziger… - Antimicrobial Agents …, 2011 - Am Soc Microbiol The effect of multiple doses of rifabutin (150 mg) on the pharmacokinetics of saquinavir-ritonavir (1,000 mg of saquinavir and 100 mg of ritonavir [1,000/100 mg]) twice daily (BID) was assessed in 25 healthy subjects. Rifabutin reduced the area under the plasma drug ... Related articles - All 3 versions
F Canducci, ER Ceresola, D Saita, Y Al-Abed… - Antiviral Research, 2011 - Elsevier Although, the antiviral activity, tolerability and convenience of protease inhibitors have improved significantly in recent years, toxicity-associated adverse events including diarrhea, lipid alterations, disturbance of glucose homeostasis and liver enzyme elevations still remain a ...
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