[HTML] from pnas.orgRK Montgomery, DL Carlone… - Proceedings of the …, 2011 - National Acad Sciences The intestinal epithelium is maintained by a population of rapidly cycling (Lgr5 + ) intestinal stem cells (ISCs). It has been postulated, however, that slowly cycling ISCs must also be present in the intestine to protect the genome from accumulating deleterious mutations and to allow ... Cited by 11 - Related articles - All 4 versions
Y Zhu, M Curtis… - Journal of virological methods, 2011 - Elsevier The aim of this study is to establish a phenotyping assay to analyze patient HBV polymerase/reverse transcriptase (RT) sequences for potential drug resistance against RT inhibitors. HBV RT (pol aa 304 to 715, including the entire RT) from clinical isolates were ... All 3 versions
[PDF] from natap.orgU Neogi, A Shet, R Shamsundar… - AIDS, 2011 - journals.lww.com The low genetic barrier to development of resistance to first generation nonnucleoside reverse transcriptase inhibitors (NNRTIs) is compounded by cross-resistance across the class that makes sequential therapy with the NNRTIs therapeutically inappropriate. Current first-line NNRTI ... Related articles - All 3 versions
T Hinkley, J Martins, C Chappey, M Haddad… - Nature Genetics, 2011 - nature.com The development of a quantitative understanding of viral evolution and the fitness landscape in HIV-1 drug resistance is a formidable challenge given the large number of available drugs and drug resistance mutations. We analyzed a dataset measuring the in vitro fitness of ... Cited by 3 - Related articles - All 3 versions
W Jia, S Wang, JW Horner, N Wang, H Wang… - The FASEB Journal, 2011 - FASEB Telomerase is tightly regulated in humans relative to mice, owing to the differential regulation of TERT genes. To explore hTERT regulation in vivo, we engineered mice with a 160-kb transgenic bacterial artificial chromosome (BAC) spanning the hTERT locus with a Renilla luciferase ... Related articles - All 3 versions
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