EO Oloo, JA Yethon, MM Ochs, B Carpick… - Journal of Biological …, 2011 - ASBMB Pneumolysin (PLY) is a cholesterol-binding, pore-forming protein toxin. It is an important virulence factor of Streptococcus pneumoniae and a key vaccine target against pneumococcal disease. We report a systematic structure-driven approach that solves a long-standing ... Related articles - All 3 versions
RM Harvey, AD Ogunniyi, AY Chen… - Infection and …, 2011 - Am Soc Microbiol Streptococcus pneumoniae is a leading cause of human diseases such as pneumonia, bacteremia, meningitis, and otitis media. Pneumolysin (Ply) is an important virulence factor of S. pneumoniae and a promising future vaccine target. However, the expansion of clones ...
[PDF] from mdpi.comC Förtsch, S Hupp, J Ma, TJ Mitchell, E Maier… - Toxins, 2011 - mdpi.com ... Article Changes in Astrocyte Shape Induced by Sublytic Concentrations of the Cholesterol- Dependent Cytolysin Pneumolysin Still ... A major pathogenic factor of S. pneumoniae is the cholesterol-dependent cytolysin, pneumolysin. It produces cell lysis at high concentrations ... Cited by 1 - Related articles - All 2 versions
C Wippel, C Förtsch, S Hupp… - Journal of Infectious …, 2011 - jid.oxfordjournals.org Background. Streptococcus pneumoniae causes serious diseases such as pneumonia and meningitis. Its major pathogenic factor is the cholesterol-dependent cytolysin pneumolysin, which produces lytic pores at high concentrations. At low concentrations, it has other effects, ...
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